A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/36 (2006.01)
Patent
CA 2489996
An adsorbent, method of removing by adsorption or adsorption apparatus whereby low density lipoprotein and fibrinogen are effectively adsorbed directly from body fluid, especially whole blood to thereby obtain body fluid having the concentration thereof lowered without minimizing the loss of valuable substances such as HDL and albumin. In particular, an adsorbent comprising a water-insoluble porous support and, fixed thereon, a tryptophan derivative and a polyanionic compound, wherein the amount of polyanionic compound fixed is in the range of 0.10 to 1.5 µmol per ml of adsorbent in wet form, and wherein the molar ratio between the amount of tryptophan derivative fixed and the amount of polyanionic compound fixed is in the range of 1 to 70. By the use of this adsorbent, low density lipoprotein and fibrinogen can be effectively adsorbed in a safe manner through whole blood treatment.
L'invention concerne un adsorbant, une m~thode de suppression par adsorption ou un appareil d'adsorption permettant d'adsorber efficacement une lipoprot~ine et un fibrinogne de faible densit~ directement ~ partir d'un liquide corporel, et notamment ~ partir du sang total, en vue d'obtenir un liquide corporel pr~sentant une concentration r~duite en lipoprot~ine/fibrinogne sans perte de substances utiles telles que la HDL et l'albumine. Plus particulirement, l'invention concerne un adsorbant comprenant un support poreux insoluble dans l'eau et, fix~ sur celui-ci, un d~riv~ de tryptophan et un compos~ polyanionique. La quantit~ de compos~ polyanionique fix~ est compris entre 0,10 et 1,5 micromole par ml d'adsorbant ~ l'~tat humide, et le rapport molaire entre la quantit~ de d~riv~ de tryptophan fix~ et la quantit~ de compos~ polyanionique fix~ est comprise entre 1 et 70. L'utilisation de cet adsorbant permet d'adsorber la lipoprot~ine et le fibrinogne de faible densit~ avec efficacit~ et de manire sÛre pendant un traitement du sang total.
Furuyoshi Shigeo
Kobayashi Akira
Nakatani Masaru
Nishimoto Takehiro
Kaneka Corporation
Osler Hoskin & Harcourt Llp
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