A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/12 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2554973
The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled PTH formulations are disclosed. Improved formulations comprising DPPC, PTH and sodium citrate which are useful in the treatment of lowered PTH conditions are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion. Kits containing receptacles of the formulations are also disclosed.
La présente invention concerne d'une manière générale des préparations possédant des particules comprenant des phospholipides, un agent bio-actif et des excipients et qui permet l'apport pulmonaire de ces particules. Cette invention concerne aussi des préparations PTH inhalées en poudre sèche. Cette invention concerne encore des préparations améliorées comprenant DPPC, PTH et du citrate de sodium qui conviennent pour le traitement d'état à niveau de PTH bas. Cette invention concerne aussi une technique d'apport pulmonaire d'un agent bio-actif comprenant l'administration dans les voies respiratoires du patient nécessitant ce traitement, d'une quantité efficace de particules comprenant un agent bio-actif ou une combinaison de ces composés en association, la libération de cet agent des particules administrées survenant de manière rapide. Cette invention concerne enfin des kits contenant des réceptacles de ces préparations.
Batycky Richard P.
Lipp Michael M.
Advanced Inhalation Research Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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