Use of cis-hydroxyitraconazole in order to avoid...

Details Use of cis-hydroxyitraconazole in order to avoid... Use of cis-hydroxyitraconazole in order to avoid...

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2271849

The invention involves prophylactic methods and methods of treatment using cis- hydroxyitraconazole, a metabolic derivative of cis-itraconazole, for the treatment or prevention of microbial, particularly fungal infection and other disorders, while avoiding the concomitant liability of adverse side effects associated with the administration of cis-itraconazole. Methods of treating or preventing such infections in the brain and other areas of CNS are also disclosed.

Cette invention se rapporte à des procédés prophylactiques et thérapeutiques qui font usage de la cis-hydroxyitraconazole, un dérivé métabolique de cis-itraconazole, pour traiter ou prévenir les infections microbiennes, et notamment les mycoses, et autres troubles, sans toutefois entraîner les effets secondaires concomitants associés à l'administration de cis-itraconale. L'invention se rapporte également à des procédés de traitement et de prévention de telles infections affectant le cerveau et d'autres parties du système nerveux central.

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