C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/4168 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2488242
The invention relates to substituted thiophene derivatives of formula (I), wherein: R1 to R8 have the meanings as cited in the claims. Medicaments containing compounds of this type are useful in preventing or treating various diseases. Thus, these compounds can be used, among other things, for treating breathing disturbances and snoring, for improving the breathing drive, for treating acute and chronic diseases, diseases triggered by ischemic and/or reperfusion events as well as by proliferative or fibrotic events, for the treatment or prophylaxis of diseases of the central nervous system, lipid metabolism and diabetes, blood clotting and parasitic infection.
L'invention concerne des dérivés de thiophène de formule (I), R1 à R8 ayant les significations données dans le descriptif. Les médicaments contenant de tels composés servent à la prévention ou au traitement de diverses maladies. Lesdits composés peuvent ainsi servir au traitement de troubles respiratoires et du ronflement, à l'amélioration de la dynamique respiratoire, au traitement de troubles graves et chroniques, de maladies provoquées par des événements ischémiques et/ou de reperfusion ou des événements fibrotiques, au traitement ou à la prophylaxie de maladies du système nerveux central, du métabolisme et du diabète, de la coagulation sanguine et des attaques par des parasites.
Bleich Markus
Gekle Michael
Heinelt Uwe
Hofmeister Armin
Lang Hans-Jochen
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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