A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61M 1/36 (2006.01)
Patent
CA 2345408
Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.
L'invention concerne des procédés de réduction de l'immunité humorale d'un sujet donné face à des agents viraux thérapeutiques immunogènes, tels que l'adénovirus, au moyen de l'immunoaphérèse. On procède au retrait de façon sélective des anticorps propres à l'agent viral thérapeutique immunogène du sang d'un sujet avant d'administrer ledit agent, par réaction extracorporelle avec un immunoabsorbant qui se lie spécifiquement à l'anticorps. Une fois cette opération réalisée, le sang est réinjecté dans le corps du sujet et l'agent thérapeutique immunogène viral lui est administré. L'invention porte également sur des kits et compositions permettant le retrait sélectif des anticorps antiviraux.
Chen Yu
Henderson Daniel R.
Yu De-Chao
Borden Ladner Gervais Llp
Calydon Inc.
Cell Genesys Inc.
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