Parenchymal hepatocyte growth substances

Details Parenchymal hepatocyte growth substances Parenchymal hepatocyte growth substances

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2158727

A novel parenchymal hepatocyte growth sub- stance originating in a human or animal liver, having an estimated molecular weight according to nonreductive SDS-PAGE of about 63,000 to about 69,000, an estimated molecular weight according to reductive SDS-PAGE of about 32,000 to about 36,000 and an estimated molecular weight according to gel filtration of about 60 to about 70 Kd; and having an activity of effecting the growth of parenchymal hepatocyte has been obtained from the hemihepatectomized tissue. Furthermore, a gene coding for the above substance has been obtained from the mRNA of the above tissue and it has thus become possible to mass-produce the above substance.

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