Derivatives of pyridinalkyl-aminoalkyl-1h-indole inhibiting...

Details Derivatives of pyridinalkyl-aminoalkyl-1h-indole inhibiting... Derivatives of pyridinalkyl-aminoalkyl-1h-indole inhibiting...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2506960

The invention relates to novel derivatives of indole of a formula (I) wherein X, Y, R1, R1', m and n are as defined in a first claim. Said compounds exhibit a high affinity with respect to the receptors 5-HT1A and a partial affinity with respect to the receptors 5-HT1D. The compounds inhibit the recapture of serotonin, exhibit agonistic and antagonistic properties with respect to said serotonin and can be used as antidepressant and anxiolitic and for curing neurogenerative disorders.

L'invention concerne des nouveaux dérivés d'indole de formule (I) dans laquelle X, Y, R?1¿, R?1'¿, m et n sont tels que définis dans la première revendication. Ces composés présentent une forte affinité envers les récepteurs 5-HT¿1A? et une affinité partielle envers les récepteurs 5-HT¿1D?. Lesdits composés inhibent la recapture de la sérotonine, présentent des propriétés agonistes et antagonistes envers la sérotonine et peuvent être utilisés en tant qu'antidépresseurs et anxiolytiques ainsi que pour traiter des maladies neurodégénératives.

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