Method for producing chiral 3,4-dehydroprolines

Details Method for producing chiral 3,4-dehydroprolines Method for producing chiral 3,4-dehydroprolines

C - Chemistry, Metallurgy

07

D

C07D 207/20 (2006.01) C07D 207/22 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2291787

The invention relates to a method for producing chiral 3,4-dehydroprolines of formula (I), in which R, R' and R'' have the meanings given in the description. The invention is characterized in that a pyrrolecarboxylic acid derivative of formula (II) is reacted first with an alkali or alkaline earth metal in ammonia and then with an aqueous salt solution or a compound having formula (III), in which X is a leaving group.

L'invention concerne un procédé de fabrication de 3,4-déhydroprolines chirales de formule (I), dans laquelle R, R' et R'' ont les significations données dans la description, caractérisé en ce qu'on fait réagir un dérivé de l'acide pyrrolcarboxylique de formule (II) dans l'ammoniac avec un métal alcalin ou alcalino-terreux, puis avec une solution de chlorure de sodium ou un composé de formule (III) dans laquelle X est un groupe partant.

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