A screening assay for antagonists of human leukocyte receptors

Details A screening assay for antagonists of human leukocyte receptors A screening assay for antagonists of human leukocyte receptors

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 31/519 (2006.01) A61K 38/13 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2436777

A method of screening compounds for their ability of inhibiting ligand-induced co-stimulatory receptor internalisation pathways in immune competent human cells is described. Said immune competent human cells are incubated at conditions capable of inducing co-stimulatory receptor internalisation in the presence of at least one test compound and the suppression of the ligand- induced co-stimulatory receptor internalisation determined. There is also described a kit for use in such a method, as well as an immunoregulatory drug capable of blocking down-modulation of a ligand-induced receptor.

L'invention concerne un dosage biologique de composants concernant leur aptitude ~ inhiber les voies d'internalisation du r~cepteur co-stimulatoire induit par un ligand dans des cellules humaines immunocomp~tentes. Ces cellules humaines immunocomp~tentes sont incub~es dans des conditions permettant d'induire l'internalisation du r~cepteur co-stimulatoire en pr~sence d'au moins un compos~ test et la suppression de l'internalisation du r~cepteur co-stimulatoire induit par un ligand. L'invention concerne ~galement un kit destin~ ~ Útre utilis~ dans un tel proc~d~, ainsi qu'un m~dicament immunor~gulateur capable de bloquer la modulation restrictive d'un r~cepteur induit par un ligand.

Affiliated with

Also associated with

Rating

A screening assay for antagonists of human leukocyte receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with A screening assay for antagonists of human leukocyte receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A screening assay for antagonists of human leukocyte receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1781465