C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/02 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2554554
A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.
La présente invention concerne une technique de traitement d'infection microbienne, y compris une infection par un pathogène protozoaire, tel que<i>Trypanosoma brucei rhodesiense</i> et <i>Plasmodium falciparum</i>, pour un sujet nécessitant ce traitement par administration à ce sujet d'une quantité efficace d'un composé imidazopyridine dicationique ou d'un composé tétrahydro-imidazopyridine dicationique. Cette invention concerne aussi des processus de synthèse de imidazopyridines dicationiques et de tétrahydro-imidazopyridines dicationiques ainsi que les nouveaux composés imidazopyridine dicationique et tétrahydro-imidazopyridine dicationique eux-mêmes.
Boykin David W.
Ismail Mohamed A.
Tidwell Richard R.
Wilson W. David
Georgia State University Research Foundation Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of North Carolina At Chapel Hill
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