Growth factor treatment for asthma

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/18 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2580107

The present invention relates to use of a growth factor which is an epidermal growth factor (EGF) analogue, a KGF or KGF analogue to treat, or protect from, 10 bronchial epithelium damage in asthma patients. Suitable EGF analogues for this purpose target the EGF receptor and exhibit ability to promote in asthma patients preferential proliferation of bronchial epithelial cells compared to airway fibroblasts.

La présente invention se rapporte à l'utilisation d'un facteur de croissance qui est un analogue d'un facteur de croissance épidermique (EGF), un facteur de croissance de kératinocytes (KGF) ou un analogue de KGF, pour le traitement des dégâts occasionnés à l'épithélium bronchique chez des patients asthmatiques, ou pour empêcher de tels dégâts chez ces patients. Les analogues d'EGF permettant d'atteindre ce but ciblent le récepteur EGF et présentent la capacité de promouvoir chez des patients asthmatiques une prolifération préférentielle des cellules épithéliales bronchiques par comparaison aux fibroblastes des voies aériennes.

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