Serum-free expansion of cells in culture

Details Serum-free expansion of cells in culture Serum-free expansion of cells in culture

G - Physics

01

N

G01N 33/50 (2006.01) C12N 5/00 (2006.01) G01N 33/52 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2632370

Methods and agents are disclosed for modulating the interaction of .beta.- catenin or .gamma.-catenin with CBP or p300. Agents that increase the binding of CBP to .beta.-catenin are associated with enhancing the .beta.-catenin related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.

L'invention porte sur des méthodes et des agents modulant l'interaction de la ß-caténine ou de la ?-caténine avec le CBP ou le p300. Les agents renforçant la fixation du CBP sur la ß-caténine sont associés à un accroissement lié à la ß-caténine de la prolifération de cellules souches adultes dont: les cellules souches hématopoïétiques, les cellules souches neurales, les cellules souches de la peau, les cellules souches du pancréas, ainsi que les cellules souches embryonnaires.

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