C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/42 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2108259
A process for identifying plasma samples containing effective antibody titers for the treatment and/or prophylaxis of in- fections caused by a respiratory virus. The process comprises contacting a plasma sample containing antibodies against a respira- tory virus with the respiratory virus. The mixture of plasma sample and virus is then contacted with a plurality of cells. The re- maining non-neutralized virus in the sample is then determined through an immunoassay following replication of the virus in the cells. Plasma samples which, at a preselected minimum antibody titer value, prevent viral replication in the cells, are then select- ed. Plasma from which the selected samples were derived are then pooled to provide an immunoglobulin preparation having in- creased effectiveness in the prophylaxis and/or treatment of infections caused by the respiratory virus.
Leszczynski Jeanne
Siber George R.
Massachusetts Health Research Institute Inc.
Smart & Biggar
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