Heterocyclic indazole derivatives

Details Heterocyclic indazole derivatives Heterocyclic indazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4196 (2006.01) A61K 31/4245 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2687162

Novel heterocyclic indazole derivatives of formula (I), wherein L, Q, R, X, Y, R3, R4 and R5 are defined as in claim 1, are SGK inhibitors and can be used for treating SGK-related diseases and disorders such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiovascular diseases and renal diseases, in general for any type of fibroses and inflammatory processes.

Nouveaux dérivés d'indazole hétérocycliques de formule (I) dans laquelle L, Q, R, X, Y, R3, R4 et R5 possèdent la signification figurant dans la revendication 1, qui sont des inhibiteurs de kinases régulées par le sérum et les glucocorticoïdes (SGK) et peuvent être utilisés pour le traitement de maladies et de troubles induits par SGK tels que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie systémique et pulmonaire, les maladies cardiovasculaires et les maladies rénales et généralement toutes les formes de fibroses et de processus inflammatoires.

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