Osteogenic growth oligopeptides as stimulants of hematopoiesis

Details Osteogenic growth oligopeptides as stimulants of hematopoiesis Osteogenic growth oligopeptides as stimulants of hematopoiesis

A - Human Necessities

61

K

A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 7/00 (2006.01) A61P 35/02 (2006.01) A61P 37/00 (2006.01) C12N 5/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2456092

The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analagous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly- Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

L'invention concerne une composition pharmaceutique renfermant comme principe actif un oligopeptide identique ou analogue à l'extrémité C du peptide de l'ostéogenèse, qui stimule la production des cellules hématopoïétiques. On utilise de préférence les oligopeptides Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. Plus spécifiquement, ces oligopeptides améliorent la prise des greffes de moelle osseuse, la reconstruction hématopoïétique, la reconstitution de moelle osseuse et la mobilisation périphérique des cellules souches embryonnaires, de préférence après une chimiothérapie ou une irradiation. L'invention concerne également des procédés de traitement et des procédés relatifs à l'utilisation des oligopeptides en question dans l'élaboration de compositions pharmaceutiques.

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