Pancam nucleic acids and polypeptides

Details Pancam nucleic acids and polypeptides Pancam nucleic acids and polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/39 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/02 (2006.01) C12P 21/02 (2006.01) C12Q 1/24 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2459985

An isolated polynucleotide encoding a novel immunoglobulin superfamily member named PanCAM (also named GP354) is provided. PanCAM has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of PanCAM indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas (especially the beta islets), the pituitary gland, and the central nervous system (CNS). Provided by the invention are isolated PanCAM related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to PanCAM, cells which produce such antibodies, and related diagnostic and therapeutic methods.

L'invention concerne un polynucléotide isolé codant pour un nouveau membre de la superfamille des immunoglobulines appelé PanCAM (également appelé GP354). PanCAM comprend un domaine transmembranaire unique prédit et cinq domaines de type immunoglobuline (Ig) dans la partie extracellulaire de la protéine. La structure protéique et la répartition tissulaire de PanCAM indiquent que cette dernière joue un rôle dans les événements de reconnaissance, de liaison, de signalisation et d'adhérence entre cellules, dans le pancréas (en particulier dans les îlots bêta), l'hypophyse, et le système nerveux central (SNC). L'invention concerne également des polynucléotides et des polypeptides isolés apparentés à PanCAM, des vecteurs et des cellules hôtes comprenant l'un de ceux-ci, des anticorps dirigés contre PanCAM, des cellules produisant de tels anticorps, et des méthodes diagnostiques et thérapeutiques connexes.

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