C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/74 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/22 (2006.01)
Patent
CA 2675115
The invention is in the field of molecular biology, and relates to recombinant engineering and protein expression. More in particular, the invention relates to nucleic acids for recombinant expression of proteins comprising sequences derived from Lactococcus and useful as promoters. The invention further relates to vectors comprising the said nucleic acids and host cells transformed therewith. The invention also covers the use of host cells comprising the said nucleic acids or vectors for expressing heterologous or homologous proteins; and also for delivery, especially therapeutic delivery, of the said proteins to subjects.
L'invention se rapporte au domaine de la biologie moléculaire et concerne l'ingénierie de la recombinaison et l'expression de protéines. Plus particulièrement, elle concerne des acides nucléiques destinés à l'expression recombinante de protéines comprenant des séquences dérivées du Lactococcus et utiles en tant que promoteurs. Elle concerne aussi des vecteurs comprenant ces acides nucléiques et des cellules hôtes transformées au moyen de ceux-ci. L'invention concerne enfin l'utilisation de cellules hôtes comprenant ces acides nucléiques ou ces vecteurs destinés à l'expression de protéines hétérologues ou homologues; et à l'administration, notamment thérapeutique, de ces protéines à des patients.
Neirynck Sabine
Steidler Lothar
Vandenbroucke Klaas
Actogenix N.v.
Smart & Biggar
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