Nucleic acids and corresponding proteins entitled 282p1g3...

Details Nucleic acids and corresponding proteins entitled 282p1g3... Nucleic acids and corresponding proteins entitled 282p1g3...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 3

Patent

CA 2493921

A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 282P1G3 can be used in active or passive immunization.

L'invention concerne un nouveau gène 282P1G3 et sa protéine codée, ainsi que des variants de celui-ci. 282P1G3 présente une expression spécifique tissulaire dans un tissu adulte normal, et est exprimée de manière aberrante dans les cancers listés dans le tableau 1. Par conséquent, 282P1G3 fournit une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 282P1G3 ou un de ces fragments, ou sa protéine codée, ou ses variants, ou un fragment de ceux-ci peuvent être utilisés pour provoquer une réponse immunitaire humorale ou cellulaire; des anticorps ou des cellules T réagissant avec 282P1G3 peuvent être utilisés pour une immunisation active ou passive.

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