C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/06 (2006.01) A61K 31/4745 (2006.01) A61K 31/519 (2006.01) C07D 513/06 (2006.01)
Patent
CA 2516705
The present invention is directed to compounds of formulae (I and II) (wherein A, D, E. X, l, m, n and R1 through R18 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
L'invention concerne des composés représentés par les formules (I et II) (dans lesquelles A, D, E. X, l, m, n et R?1¿ à R?18¿ sont tels que définis dans la description) utilisés comme modulateurs de l'activité des récepteurs de la chimiokine. Ces composés sont utilisés, en particulier, comme modulateurs du récepteur de la chimiokine CCR-2.
Goble Stephen D.
Pasternak Alexander
Tang Cheng
Yang Lihu
Zhou Changyou
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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