Styryl benzimidazole derivatives as inhibitors of smooth...

Details Styryl benzimidazole derivatives as inhibitors of smooth... Styryl benzimidazole derivatives as inhibitors of smooth...

C - Chemistry, Metallurgy

07

D

C07D 235/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4184 (2006.01) A61K 31/44 (2006.01) C07D 235/08 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2223585

Disclosed herein are compounds of formula (I) or (II), wherein R is phenyl or substituted phenyl; or R is furyl, pyridyl or quinolinyl; R1 and R2 are hydrogen, halogen, alkyl, alkoxy, nitro, carboxyl, alkoxycarbonyl or aryloxycarbonyl; R3 is hydrogen, alkyl, aryl or arylalkyl; R4 and R5 are hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.

Composés de formule (I) ou (II), dans lesquelles R est phényle ou phényle substitué; ou R est furyle, pyridyle ou quinolinyle; R¿1? et R¿2? sont hydrogène, halogène, alkyle, alcoxy, nitro, carboxyle, alcoxy-carbonyle ou aryloxycarbonyle; R¿3? est hydrogène, alkyle, aryle ou arylalkyle; R¿4? et R¿5? sont hydrogène ou alkyle; ou leur sel pharmaceutiquement acceptable, servant d'inhibiteurs de la prolifération des cellules musculaires lisses.

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