C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/10 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2580151
The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected .beta.-lactams with a lipase from Candida antarcticawith high stereospecificity. The presence of a carbamate protecting group, such as the tert-butoxycarbonyl group protecting group, on the (3-lactam enhances enzyme catalysis and stereoselectivity.
La présente invention concerne des procédés enzymatiques permettant de générer des produits stéréoïsomériquement purs par résolution d'un mélange racémique de ß-lactams N-protégés avec une lipase issue de Candida antarctica de haute stéréospécificité. La présence d'un groupe protecteur carbamate, et notamment tert-butoxycarbonyle, sur le ß-lactam renforce la catalyse et la stéréosélectivité des enzymes.
Mbm Intellectual Property Law Llp
Rigel Pharmaceuticals Inc.
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