Methods of treating retroviral infection

Details Methods of treating retroviral infection Methods of treating retroviral infection

A - Human Necessities

61

K

A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) C12Q 1/37 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2030254

X-8100A Abstract The present invention provides antiretroviral methods using the compounds of formula (I) X-Xl-Pl-Val-Z-Leu-P2-Y wherein: Z is Statine or ACHPA; and when Z is Statine, X is H-Pro-paF, H-Pro-His, Ac-Tyr, Ac-NA, Ac-Trp, Ac-YOM, Ac-Phe, Ac-paF, H-His, Ac-His or Ac-Gly-Tyr-YOM, X1 is Pro Ser or Ac, P1 is Phe, paF or YOM, P2 is Phe or Leu, and Y is NH2, paF-NH2, His-NH2, Phe-NH2 or Tyr-LeU-NH2, provided that when X1 is Ac then there is no X residue; and when Z is ACHPA, X is H-Pro-His, H-Pro-paF, Ac paF or Ac-His, P1 is Phe, P2 is Phe, and Y is paF-NH2 and His-NH2. The invention further provides methods for determining the retroviral protease inhibitory activity of compounds using viral polypeptides made using recombinant DNA techniques.

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