C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 11/00 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2368760
Disclosed are polypeptide analogs of FLINT, polydeoxynucleotides encoding FLINT analogs, and methods of using FLINT analogs and polydeoxynucleotides. The FLINT analogs of the invention include polypeptides having the amino acid sequence of FLINT, modified at one or more positions with amino acid substitutions, and include fragments thereof, as well as Fc fusions comprising FLINT and FLINT analogs.
L'invention concerne des analogues polypeptidiques de FLINT (FAS Ligand Inhibitory proteins/protéines inhibitrices de ligands FAS), des polydésoxynucléotides codant pour les analogues de FLINT et des méthodes d'utilisation de polydésoxynucléotides et d'analogues de FLINT. Les analogues de FLINT de l'invention comprennent des polypeptides possédant la séquence d'acides aminés de FLINT, modifiée au niveau d'une ou plusieurs positions par des substitutions d'acide aminé, et comprennent des fragments de celles-ci, ainsi que des fusions Fc comprenant FLINT et des analogues de FLINT.
Becker Gerald Wayne
Cohen Fredric Jay
Gonzalez-Dewhitt Patricia Ann
Hale John Edward
Micanovic Radmila
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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