Treating bone-related disorders with selective androgen...

A - Human Necessities – 61 – K

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Details

A61K 31/277 (2006.01) A61K 31/167 (2006.01) A61P 19/08 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2535953

This invention provides method of treating, preventing, suppressing, inhibiting, or reducing the risk of developing a bone-related disorder, for example osteoporosis, osteopenia, increased bone resorption, bone fracture, bone frailty and/or loss of bone mineral density (BMD), by administrating a therapeutically effective amount of a selective androgen receptor modulator (SARM) and/or its analogue, derivative, isomer, metabolite pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof. The invention also provides methods of decreasing fat mass (FM) and increasing lean mass, comprising administering same.

L'invention concerne un procédé destiné au traitement, à la prévention, à la suppression, à l'inhibition ou à la réduction des risqués liés au développement d'un trouble osseux, par exemple, de l'ostéoporose, de l'ostéopénie, de la résorption osseuse plus intense, de la fracture osseuse, de la fragilité des os et/ou de la perte de la densité minérale osseuse (BMD), par l'administration d'une quantité thérapeutiquement efficace d'un modulateur de récepteur d'androgène sélectif (SARM) et/ou de son analogue, dérivé, sel de métabolite pharmaceutiquement acceptable, produit pharmaceutique, hydrate, N-oxyde ou de n'importe quelle combinaison de ceux-ci. L'invention concerne aussi des procédés pour réduire la masse lipidique (FM) et d'augmenter la masse maigre, qui consistent à administrer ces médicaments.

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