Recombinant (alpha)-l-iduronidase, methods for producing and...

Details Recombinant (alpha)-l-iduronidase, methods for producing and... Recombinant (alpha)-l-iduronidase, methods for producing and...

C - Chemistry, Metallurgy

12

N

C12N 15/56 (2006.01) A61K 38/47 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 9/24 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328518

The present invention provides a recombinant .alpha.-L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including .alpha.-L-iduronidase deficiency and mucopolysaccharidosis I (MPS I).

La présente invention concerne une .alpha.-L-iduronidase, des fragments et des mutants biologiquement actifs de celle-ci, des procédés de production et de purification de cette enzyme, ainsi que des méthodes de traitement de certaines affections génétiques comprenant un déficit en .alpha.-L-iduronidase et la mucopolysaccharidose I (MPS I).

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