C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 309/80 (2006.01) A61P 9/12 (2006.01) A61P 25/22 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2702468
Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder, including hypertension and cardiac hypertrophy.
La présente invention concerne une hydrolase d'amide d'acide gras, qui est un enzyme responsable de la dégradation de l'oléamide (un lipide endogène inducteur de sommeil) et de l'anandamide (un ligand endogène pour les récepteurs cannabinoïdes). La présente invention présente ici de puissants inhibiteurs de l'hydrolase d'amide d'acide gras et des procédés permettant de les utiliser dans le traitement d'une variété de troubles, notamment l'hypertension et l'hypertrophie cardiaque.
Kunos George
Makriyannis Alexandros
Smart & Biggar
The Government Of The United States Of America As Represented By
University Of Connecticut
LandOfFree
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