Use of il-13 to induce 15-lipoxygenase

Details Use of il-13 to induce 15-lipoxygenase Use of il-13 to induce 15-lipoxygenase

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 35/12 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2221449

The present invention is based on the discovery that IL-13 induces 15-LO in human monocytes. Surprisingly, it has been found that IL-13 is about ten-fold more active, on a molar basis, than IL-4 in inducing 15-LO. IL-13 is therefore an effective therapeutic for inflammatory conditions responsive to products of 15-LO activity, including 15-S-HETE and LXA4. By enhancing endogenous pathways leading to synthesis of endogenous anti-inflammatory molecules, administration of IL-13 results in inhibition of the end effectors of the inflammatory process itself. The underlying strategy is therefore to direct intervention to specific pathogenic molecules, rather than the current method of treating symptoms of inflammation.

La présente invention se fonde sur la découverte que l'IL-13 favorise la production de 15-LO chez les monocytes humains. Contrairement à ce qu'on pourrait attendre, l'IL-13 s'avère environ dix fois plus active, sur une base molaire, que l'IL-4 dans la production de 15-LO. L'IL-13 est donc une substance thérapeutique efficace dans le cas d'états inflammatoires réagissant aux produits de l'activité du 15-LO, notamment 15-S-HETE et LXA¿4?. En favorisant des voies endogènes conduisant à la synthèse de molécules anti-inflammatoires endogènes, l'administration d'IL-13 aboutit à l'inhibition des effecteurs terminaux du processus inflammatoire lui-même. La stratégie employée consiste donc à intervenir directement sur des molécules pathogènes spécifiques, par opposition à la méthode actuelle qui consiste à traiter les symptômes de l'inflammation.

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