C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2315239
A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated Mammastatin.
L'invention porte sur une séquence d'acide nucléique codant la mammastatine, un inhibiteur spécifique de la prolifération cellulaire mammaire. La mammastatine est codée par une séquence d'acide nucléique unique et a un poids moléculaire approximatif de 44 kDa sous sa forme inactive, non phosphorylée. Les cellules mammaires normales expriment les formes phosphorylées ayant des poids moléculaires approximatifs de 53 kDa et 49 kDa. Les cellules mammaires métastatiques soit n'expriment pas du tout la Mammastatine, soit expriment les formes phosphorylées de 53 kDa ou 49 kDa. Les cellules cancéreuses mammaires sont inhibées dans leur prolifération par l'administration de la mammastatine phosphorylée.
Robic
The Regents Of The University Of Michigan
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