A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/08 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2335364
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
L'invention concerne un anticorps bi-spécifique ou un fragment d'anticorps pourvu d'au moins un bras qui se lie spécifiquement à un tissu ciblé et d'un autre bras qui se lie spécifiquement à un conjugué pouvant être visé. Ce dernier comporte une partie vecteur qui comporte ou porte au moins un épitope reconnaissable par au moins un arbre dudit anticorps bi-spécifique ou dudit fragment d'anticorps. Le conjugué pouvant être visé comporte également un ou plusieurs agents ou enzymes thérapeutiques ou diagnostiques. L'invention concerne également des produits de recombinaison et des méthodes de production et d'utilisation de ces anticorps bi-spécifiques et de ces fragments d'anticorps.
Griffiths Gary L.
Hansen Hans J.
Leung Shui-On
Mcbride William J.
Qu Zhengxing
Immunomedics Inc.
Smart & Biggar
LandOfFree
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