Use of alginate matrices to control cell growth

A - Human Necessities – 61 – F

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A61F 2/02 (2006.01)

Patent

CA 2548305

Methods of inhibiting proliferation of a plurality of proliferating cells are disclosed. Methods of inhibiting cell overgrowth on compositions that are in an animal~s body are disclosed. Methods of inhibiting cell overgrowth on a device that is in an animal~s body are disclosed. Devices that have on their exterior surface an alginate matrix that comprises Strontium are disclosed. Compositions comprising an alginate body and alginate sheets that each comprise a single layer of cells coating the exterior surface of the alginate body are disclosed. Methods of preparing an artificial tissue are disclosed. Devices comprising cells encapsulated within an alginate matrix and/or maintained as a monolayer on an alginate body, and methods of making and using the same are disclosed. Methods of coating compositions and devices are disclosed.

La présente invention concerne des procédés permettant d'inhiber la prolifération de plusieurs cellules proliférantes. Cette invention concerne également des procédés permettant d'inhiber la prolifération cellulaire dans des compositions contenues dans le corps d'un animal. L'invention concerne également des procédés permettant d'inhiber la prolifération cellulaire sur un dispositif placé dans le corps d'un animal. On décrit également des dispositifs présentant, sur leur surface extérieure, une matrice d'alginate qui comprend du strontium. En outre, l'invention concerne des compositions contenant un corps d'alginate et des feuilles d'alginate comprenant, chacune, une seule couche de cellules enrobant la surface extérieure du corps d'alginate. Des procédés permettant de préparer un tissu artificiel sont également décrits dans cette invention, ainsi que des dispositifs comprenant des cellules encapsulées dans une matrice d'alginate et/ou conservées en tant que monocouche sur un corps alginate ; des procédés permettant d'élaborer et d'utiliser de tels dispositifs, et des procédés permettant d'enduire les compositions et les dispositifs.

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