Stabilization of radionuclide-containing compositions

Details Stabilization of radionuclide-containing compositions Stabilization of radionuclide-containing compositions

A - Human Necessities

61

K

A61K 51/00 (2006.01) A61K 51/04 (2006.01) A61M 36/14 (2006.01)

Patent

CA 2448077

Described are methods for stabilizing radionuclide-containing compositions against degradation caused by free radicals generated from the radionuclide. Iodide ions stabilize the radionuclide-containing compositions by acting as scavengers to generated free radicals, thus, preventing or lessening degradation therefrom. Among the preferred radionuclide-containing compositions to be stabilized are complexes of a complexing agent with a radionuclide complexed therewith, such as a diagnostic agent having a specific binding peptide linked to a metal ion-complexing moiety which is complexed with a radionuclide, such as technetium-99m (Tc-99m). Also included in the invention are compositions of radionuclide-containing compounds or complexes with iodide or an iodide ion-providing component, compositions of compounds or complexing agents that will be associated with a radionuclide and kits containing any combination of radionuclides, radionuclide generators, complexing agents or compounds which are associated with or will be associated with radionuclides and iodide or iodide-providing components.

L'invention concerne des procédés destinés à la stabilisation de compositions contenant un radionucléide contre toute dégradation induite par des radicaux libres générés par le radionucléide. Les ions iodure stabilisent les compositions contenant un radionucléide en agissant comme phagocyte de radicaux libres empêchant ou réduisant la dégradation induite par ces derniers. Certaines des compositions préférées à stabiliser, contenant un radionucléide, sont des complexes formés par un agent complexant combiné avec un radionucléide, tel qu'un agent de diagnostic ayant un peptide de liaison spécifique lié à une fraction complexant les ions métalliques combiné avec un radionucléide, tel que le technétium 99 m (Tc-99m). L'invention concerne également des compositions de composés ou de complexes contenant un radionucléide combinés avec de l'iodure ou un composé fournissant des ions iodure, des compositions de composés ou des agents complexants qui seront associés à un radionucléide et des nécessaires contenant des mélanges de radionucléides, des générateurs de radionucléide, des agents complexants ou des composés qui sont associés ou qui seront associés à des radionucléides et de l'iodure ou des composants fournissant de l'iodure.

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