Combinations of vasoactive agents and their use in the...

A - Human Necessities – 61 – K

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A61K 36/53 (2006.01) A61K 31/352 (2006.01) A61K 36/16 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2532825

This invention relates to combinations of vasoactive substances which are useful in the treatment of sexual dysfunctions associated with poor local blood supply and/or insufficient lubrication. The active compounds are selected from a: - esculoside or visnadine; - forskolin or extracts containing it, or alternatively, purified lipophilic extracts of plants of the genus Ipomea; - esters of ximenynic acid; - optionally, at least one compound selected from a icarin or derivatives or extracts thereof which contain it, amentoflavone, and Gingko biloba dimeric flavones. The combination of these vasoactive substances is incorporated in gels and lotions designed to be applied to the genital organs. These formulations are useful in inducing erection of the male and female sex organs and enhancing orgasm and sexual performance. The formulations are particularly useful in the treatment of female sexual dysfunctions.

L'invention concerne des combinaisons de substances vasoactives utiles dans le traitement de dysfonctionnements sexuels associées à de faibles réserves de sang local et/ou à une lubrification insuffisante. Ces composés actifs sont choisis parmi : - l'esculoside ou la visnadine; - la forskoline ou des extraits la contenant ou, dans un autre mode de réalisation, des extraits de plantes lipophiles du genre <i>Ipomea</i>; - des esters d'acide ximénique; - éventuellement, au moins un composé choisi parmi une icarine ou des dérivés ou des extraits de celle-ci qui la contiennent, une amentoflavone, et des flavones dimériques <i>Gingko biloba</i>. La combinaison de ces substances vasoactives est introduite dans des gènes et des lotions destinées à être appliquées sur des organes génitaux. Ces formulations sont utiles en vue d'induire l'érection des organes sexuels masculin et féminin et en vue de favoriser l'orgasme et d'améliorer les performances sexuelles. Ces formulations sont particulièrement utiles dans le traitement des dysfonctionnements sexuels féminins.

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