Compositions and methods for fgf receptor kinases inhibitors

Details Compositions and methods for fgf receptor kinases inhibitors Compositions and methods for fgf receptor kinases inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/519 (2006.01) A61K 31/5355 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2650611

Described are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent disease or disordered associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activity of kinases such as AbI, ALK, AMPK, Aurora, AxI, Bcr-Abl, BIK, Bmx, BRK, BTK, c-Kit, CSK, cSrc, CDKl, CHK2, CKl, CK2, CaMKII, CaMKIV, DYRK2, EGFR, EphBl, FES, FGFRl, FGFR2, FGFR3, Fltl, FlO, FMS, Fyn, GSK3.beta., IGF lR, IKK.alpha. DCK.beta., IR, IRAK4, ITK, JAK2, JAK3, JNKl.alpha.l, JNK2.alpha., KDR, Lck, LYN, MAPKl, MAPKAP-K2, MEKl, MET, MKK4, MKK6, MST2, NEK2, NLK, p70S6K, PAK2, PDGFR, PDGFR.alpha., PDKl, Pim-2, Plk3, PKA, PKB.alpha., PKC.alpha. PKCtheta, PKD2, c-Raf, RET, ROCK-I1 ROCK-II, Ron, Ros, Rskl, SAPK2a, SAPK2b, SAPK3, SAPK4, SGK, SIK, Syk, Tie2, TrkB, WNK3, and ZAP-70.

La présente invention concerne des composés, des compositions pharmaceutiques contenant lesdits composés, et des procédés d'utilisation desdits composés, en vue du traitement ou de la prévention de maladies ou de troubles associés avec une activité kinase anormale ou déréglée, en particulier des maladies ou des troubles qui impliquent une activité anormale de kinases telles que AbI, ALK, AMPK, Aurora, AxI, Bcr-Abl, BIK, Bmx, BRK, BTK, c-Kit, CSK, cSrc, CDKl, CHK2, CKl, CK2, CaMKII, CaMKIV, DYRK2, EGFR, EphBl, FES, FGFR1, FGFR2, FGFR3, Fltl, FlO, FMS, Fyn, GSK3.beta., IGF lR, IKK.alpha. DCK.beta., IR, IRAK4, ITK, JAK2, JAK3, JNKl.alpha.l, JNK2.alpha., KDR, Lck, LYN, MAPKl, MAPKAP-K2, MEKl, MET, MKK4, MKK6, MST2, NEK2, NLK, p70S6K, PAK2, PDGFR, PDGFR.alpha., PDKl, Pim-2, Plk3, PKA, PKB.alpha., PKC.alpha. PKCthêta, PKD2, c-Raf, RET, ROCK-I1 ROCK-II, Ron, Ros, Rskl, SAPK2a, SAPK2b, SAPK3, SAPK4, SGK, SIK, Syk, Tie2, TrkB, WNK3, et ZAP-70.

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