A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/436 (2006.01) A61K 31/325 (2006.01) A61K 31/352 (2006.01) A61K 31/36 (2006.01) A61K 31/366 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4523 (2006.01) A61K 31/475 (2006.01) A61K 31/496 (2006.01) A61K 31/7048 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2612829
A pharmaceutical composition comprising a CYP3A4 inhibitor and tacrolimus or an analogue thereof, wherein the composition upon administration to a human in need thereof results in a relative AUCinvention/AUC separate value of tacrolimus of at least about 1.1 , the AUC values being determined under similar conditions and the AUCseparate value is determined after administration of tacrolimus and CYP3A4 inhibitor in separate dosage forms.
Cette invention concerne une composition pharmaceutique comprenant un inhibiteur CYP3A4 et du tacrolimus ou un analogue de celui-ci. La composition, lorsqu'elle est administrée à un sujet humain qui le nécessite, permet d'obtenir une valeur relative AUCinvention/AUC séparé de tacrolimus d'au moins environ 1.1; les valeurs AUC étant déterminées dans des conditions similaires et la valeur AUCseparé étant déterminée après administration du tacrolimus et de l'inhibiteur CYP3A4 dans des formes posologiques séparées.
Lifecycle Pharma A/s
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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