C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2279554
Provided are purified and isolated VEGF-C polypeptides capable of binding to at least one of KDR receptor tyrosine kinase (VEGFR-2) and Flt4 receptor tyrosine kinase (VEGFR-3); analogs of such peptides that have VEGF-C-like or VEGF-like biological activities or that are VEGF or VEGF-C inhibitors; polynucleotides encoding the polypeptides; vectors and host cells that embody the polynucleotides; pharmaceutical compositions and diagnostic reagents comprising the polypeptides; and methods of making and using the polypeptides.
Polypeptides VEGF-C purifiés et isolés, capables de se lier à au moins une des tyrosine kinases suivantes: tyrosine kinase à récepteur KDR (VEGFR-2) et tyrosine kinase à récepteur Flt4 (VEGFR-3). L'invention concerne également des analogues de tels peptides, présentant des activités biologiques de type VEGF-C ou VEGF ou qui sont des inhibiteurs de VEGF ou de VEGF-C, ainsi que des polynucléotides codant ces polypeptides, des vecteurs et cellules hôtes qui contiennent ces polynucléotides, des compositions pharmaceutiques et réactifs pour diagnostic contenant ces polypeptides et des procédés pour produire et utiliser ces polypeptides.
Alitalo Kari
Joukov Vladimir
Helsinki University Licensing Ltd. Oy
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
The Ludwig Institute For Cancer Research
Vegenics Limited
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