C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2439679
This invention relates to a method for assaying activity of the enzyme spermidine/spermine N1-acetyltransferase (SSAT) using SSAT substrates by detecting acetylated forms of the SSAT substrates. SSAT substrates may include amantadine wherein metabolism of amantadine occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolite N- acetylamantadine.
L'invention concerne un procédé de test de l'activité de l'enzyme spermidine/spermine N¿1?-acétyltransférase (SSAT) faisant intervenir des substrats SSAT par détection des formes acétylées de ces substrats. Les substrats SSAT peuvent contenir de l'amantadine, le métabolisme de l'amantadine ayant lieu en partie par l'action de l'enzyme SSAT inductible afin de produire un métabolite N-acétylamantadine acétylé.
Bras Alvaro P. M.
Sitar Daniel S.
Gowling Lafleur Henderson Llp
University Of Manitoba
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