Coconjugate vaccines comprising immunogenic protein, hiv...

Details Coconjugate vaccines comprising immunogenic protein, hiv... Coconjugate vaccines comprising immunogenic protein, hiv...

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) A61K 39/39 (2006.01) A61K 39/42 (2006.01) C07K 1/00 (2006.01) C07K 4/04 (2006.01) C07K 7/54 (2006.01) C07K 14/16 (2006.01) C07K 14/22 (2006.01) C07K 16/10 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2047073

115/GHB34 CASE 18152IA TITLE OF THE INVENTION COCONJUGATE VACCINES COMPRISING IMMUNOGENIC PROTEIN, HIV RELATED PEPTIDES, AND ANIONIC MOIETIES ABSTRACT OF THE DISCLOSURE A novel coconjugate comprising an immunogenic protein or protein complex having a first set of covalent linkages to low molecular weight moieties, -a-, which have an anionic or polyanionic character at physiological pH, and a second set of covalent linkages to peptides comprising Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinants (PNDs), or peptides immunologically equivalent therewith, is useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS), or for treating humans afflicted with HIV infection or disease.

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