Therapeutic or prophylactic agent for dyskinesia

Details Therapeutic or prophylactic agent for dyskinesia Therapeutic or prophylactic agent for dyskinesia

A - Human Necessities

61

K

A61K 31/485 (2006.01) A61P 25/14 (2006.01) C07D 489/02 (2006.01)

Patent

CA 2685126

Disclosed is a medicinal agent which has a high therapeutic or prophylactic effect on dyskinesia, does not cause the worsening of the condition of the underlying disease, and has fewer adverse side effects. Specifically disclosed is a therapeutic or prophylactic agent for dyskinesia, which comprises a compound having a 4,5-epoxymorphinan skeleton represented by the general formula (I) or a pharmacologically acceptable acid addition salt thereof as an active ingredient. (I) wherein the double line formed by the dashed line and the solid line represents a double or single bond; R1 represents a cycloalkylalkyl having 4 to 7 carbon atoms; R2 represents a linear or branched alkyl having 1 to 5 carbon atoms; and B represents -CH=CH-.

L'invention concerne un agent médicinal ayant un effet thérapeutique ou prophylactique important sur la dyskinésie et qui ne provoque pas la dégénération de l'affection sous-jacente, et ne présente que peu d'effets secondaires. L'invention concerne notamment un agent thérapeutique ou prophylactique de la dyskinésie qui comprend un composé ayant un squelette 4,5-époxymorphinane représenté par la formule générale (I) ou un sel d'addition d'acide pharmacologiquement acceptable de ce composé comme ingrédient actif. Dans la formule (I), la double ligne formée par la ligne pointillée et la ligne continue représente une liaison double ou simple; R1 représente un cycloalkyle possédant 4 à 7 atomes de carbone; R2 représente un alkyle linéaire ou ramifié possédant 1 à 5 atomes de carbone et B représente -CH=CH-.

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