Protein non-absorptive polyurea-polyurethane polymer coated...

A - Human Necessities – 61 – L

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A61L 31/00 (2006.01) A61L 33/00 (2006.01) A61L 33/06 (2006.01) B01D 15/08 (2006.01) B01J 20/32 (2006.01) C08G 18/10 (2006.01) C08G 18/48 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2061664

Abstract of the Invention Polymer-coated medical and laboratory devices are disclosed which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The polyurea-polyurethane coatings of this invention are prepared from high molecular weight isocyanate end-capped prepolymers substantially or exclusively comprised of ethylene oxide units. At least 75%, preferably at least 90%, of the prepolymer units are oxyethylene-based diols or polyols having molecular weights of about 7000-30,000, with essentially all of the hydroxyl groups capped with polyisocyanate prior to formation of the hydrated polymer coating.

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