Neural progenitor cells

Details Neural progenitor cells Neural progenitor cells

C - Chemistry, Metallurgy

12

N

C12N 5/079 (2010.01) A61K 35/30 (2006.01) A61K 38/18 (2006.01) A61P 25/00 (2006.01) C12Q 1/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2454276

The present invention is related to the discovery of a novel class of neural progenitor cells, which proliferate in response to platelet derived growth factor (PDGF) and differentiate into neurons and oligodendrocytes but not astrocytes. Progeny of the progenitor cells can be obtained by culturing brain tissue in PDGF without serum, epidermal growth factor (EGF), fibroblast growth factor 2, or transforming growth factor alpha. Upon subculturing into EGF- containing media, these progeny cells can proliferate and form neurospheres, whereas PDGF has no such effect.

La présente invention concerne la découverte d'une nouvelle classe de cellules progénitrices neuronales qui prolifèrent en réponse au facteur de croissance humain dérivé des plaquettes (PDGF) et se différentient en neurones et oligodendrocytes mais non pas en astrocytes. La progéniture des cellules progénitrices peut s'obtenir par la culture du tissu de cerveau dans le PDGF sans sérum, du facteur de croissance épidermique (EGF), du facteur de croissance des fibroblastes 2 ou par la transformation du facteur de croissance alpha. Après la sous-culture dans un milieu contenant de l'EGF, ces cellules progénitrices peuvent proliférer et former des neurosphères alors que le PDGF n'a pas cet effet.

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