A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2277519
The invention involves identification of a mechanism of .beta.-amyloid peptide cytotoxicity, which enables treatment of conditions caused by .beta.-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of .beta.-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a .beta.-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic .beta.-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of .beta.-amyloid peptides and the neurotoxic effects of such aggregates.
L'invention concerne l'identification d'un mécanisme de cytotoxicité d'un peptide .beta.-amyloïde, permettant le traitement d'affections provoquées par des agrégats de peptides .beta.-amyloïdes par administration de composés s'opposant au mécanisme de cytotoxicité. L'invention comprend l'identification et l'isolement de composés pouvant s'opposer à l'agrégation de peptides .beta.-amyloïdes et aux effets neurotoxiques de tels agrégats. Les composés comprennent des peptides isolés sélectionnés pour leur capacité à former un complexe avec un peptide .beta.-amyloïde, ou dérivent de peptides ainsi sélectionnés. L'invention concerne également des méthodes de traitement d'affections découlant d'agrégats de peptides .beta.-amyloïdes neurotoxiques, ainsi que des préparations pharmaceutiques. L'invention concerne enfin des méthodes de sélection de composés supplémentaires pouvant s'opposer à l'agrégation de peptides .beta.-amyloïdes et aux effets neurotoxiques de tels agrégats.
Blanchard Barbara J.
Ingram Vernon M.
Massachusetts Institute Of Technology
Smart & Biggar
LandOfFree
Treatments for neurotoxicity in alzheimer's disease by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatments for neurotoxicity in alzheimer's disease by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatments for neurotoxicity in alzheimer's disease by... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1789691