Benzyl piperidine derivatives as pharmaceutical agents

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/62 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/455 (2006.01) C07D 211/20 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 211/54 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2220504

The invention is concerned with compounds of general formula (I) wherein: A signifies A1, A2, A3, A4, A5, A6, A7 or A8; n signifies 0-2; B signifies B1, B2 or B3; R1, R2 and R3 each independently signify hydrogen, amino, nitro, halogen, lower-alkyl or lower-alkoxy; R4, R5 and R6 each independently signify hydrogen, nitro, halogen, lower-alkyl, lower-alkoxy, cyano, trifluoromethyl, amino, lower-alkylamino or di-lower-alkylamino; R7, R8 and R9 each independently signify hydrogen, amino or nitro, as well as pharmaceutically acceptable salts of compounds of formula (I). These compounds can be used in the control of psychotic disorders which are caused by damage to the dopamine system.

Composés de formule générale (I) dans laquelle A représente A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, A?7¿ ou A?8¿; n représente 0 à 2, B représente B?1¿, B?2¿ ou B?3¿; R?1¿, R?2¿ et R?3¿ représentent chacun indépendamment hydrogène, amino, nitro, halogène, alkyle inférieur ou alcoxy inférieur; R?4¿, R?5¿ et R?6¿ représentent chacun indépendamment hydrogène, nitro, halogène, alkyle inférieur, alcoxy inférieur, cyano, trifluorométhyle, amino, alkylamino inférieur ou di-alkylamino inférieur; R?7¿, R?8¿ et R?9¿ représentent chacun indépendamment hydrogène, amino ou nitro, ainsi que sels pharmaceutiquement acceptables des composés de formule (I). Lesdits composés peuvent être utilisés pour lutter contre des troubles psychotiques qui sont causés par une altération du système de la dopamine.

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