Process for the preparation of famciclovir

Details Process for the preparation of famciclovir Process for the preparation of famciclovir

C - Chemistry, Metallurgy

07

D

C07D 473/32 (2006.01)

Patent

CA 2522573

The invention provides processes for making famciclovir with low levels of undesirable by-products. The present invention discloses a process comprises reacting a compound of formula I (acetic acid 2-acetoxymethyl-4-(5-amino-7- chloro-imidazo [4,5-b]pyridin-3-yl)-butyl ester) in the presence of a palladium on charcoal catalyst in a C1-C6 alkyl acetate and ammonium formate. The present invention further discloses a process comprises reacting a compound of formula I (acetic acid 2-~ acetoxymethyl-4-(5-amino-7-chloro- imidazo[4,5-b]pyridin-3-yl)-butyl ester) in the presence of a palladium on charcoal catalyst in a mixture of a C1-C6 alkyl acetate, a C1-C4 alcohol and ammonium formate.

L'invention concerne des procédés de fabrication de famciclovir avec des faibles doses de sous-produits indésirables. L'invention porte sur un procédé qui consiste à faire réagir un composé de formule I (ester de 2-acétoxyméthyl-4-(5-amino-7-chloro-imidazo [4,5-b]pyridin-3-yl)-butylique d'acide acétique) en présence d'un palladium sur un catalyseur au charbon dans un mélange d'acétate d'alkyle C¿1?-C¿6 ?et de formate d'ammonium. L'invention porte également sur un procédé qui consiste à faire réagir un composé de formule I (ester de 2-acétoxyméthyl-4-(5-amino-7-chloro-imidazo [4,5-b]pyridin-3-yl)-butylique d'acide acétique) en présence d'un palladium sur un catalyseur au charbon dans un mélange d'acétate d'alkyle C¿1?-C¿6?, d'un alcool C¿1?-C<SB>4</SB> et d'un formate d'ammonium.

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