Substituted 8-arylquinoline pde4 inhibitors

Details Substituted 8-arylquinoline pde4 inhibitors Substituted 8-arylquinoline pde4 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 29/00 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 401/08 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 405/08 (2006.01) C07D 405/10 (2006.01) C07D 413/08 (2006.01) C07D 413/10 (2006.01) C07D 417/08 (2006.01) C07D 417/10 (2006.01) C07D 417/12 (2006.01) C07F 9/60 (2006.01) C07F 9/6571 (2006.01)

Patent

CA 2450686

8-arylquinolines of formula(I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases. R1-R7 and Ar are as in claim 1.

Les 8-arylquinones (I) dans lesquelles le groupe aryle à la position 8 contient un pont <i>meta</i> à deux atomes vers un groupe phényle ou pyridyle à substitution facultative, sont des inhibiteurs de PDE4 utiles pour traiter l'asthme, la bronchite chronique, les maladies pulmonaires obstructives chroniques, l'arthrite, le syndrome de détresse respiratoire, la rhinite allergique, l'inflammation neurogénique, la douleur, la polyarthrite rhumatoïde ainsi que d'autres maladies, et ont la formule (I) dans laquelle R?1¿-R?7¿ et Ar ont la notation définie dans la revendication 1.

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