Preparation for use of aspartate and vitamin b12 or biotin...

A - Human Necessities – 61 – K

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Details

A61K 38/02 (2006.01) A61K 31/4188 (2006.01) A61K 31/714 (2006.01) A61K 38/16 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2574423

It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, especially in relative absence of glutamate equivalents, improve the metabolism of ketobodies and/or lactate in a mammal's body, especially in diseased or traumatic conditions. As a result, levels of ketobodies and lactate can be decreased and unphysicologically high acidity normalised. Thus, it is an object of the invention to provide an enteral nutritional or a pharmaceutical composition for the treatment and/or prevention of disturbed ketone and lactate metabolism, i.e. elevated concentrations of ketone bodies, lactate and/or other organic acids and/or insufficient pH homeostasis, especially elevated concentrations of ketone bodies and/or lactate, in a mammal's blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B12 and/or biotin, preferably in relative absence of glutamate equivalents.

Il s'avère que des quantités élevées d'équivalents en aspartate en association avec la vitamine B12 et/ou la biotine, notamment en l'absence relative d'équivalents en glutamate, améliorent le métabolisme des corps cétoniques et/ou du lactate dans un corps mammalien, notamment concernant des états pathologiques ou traumatiques. Il est donc possible de réduire les taux de corps cétoniques et du lactate et de normaliser l'acidité élevée de manière non physiologique. L'invention porte, en conséquence, sur des aliments fonctionnels s'administrant par voie entérale ou sur une composition pharmaceutique destinée au traitement et/ou à la prévention du métabolisme perturbé des cétones et du lactate, à savoir par des taux élevés de corps cétoniques, de lactate et/ou d'autres acides organiques et/ou par l'homéostase à pH insuffisant, notamment des taux élevés de corps cétoniques et/ou de lactate dans le sang d'un mammifère. La composition comprend des quantités élevées d'équivalents en aspartate en association avec la vitamine B12 et/ou la biotine, de préférence en l'absence relative d'équivalents en glutamate.

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