Stem cell populations and methods of use

Details Stem cell populations and methods of use Stem cell populations and methods of use

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/074 (2010.01) A61K 35/28 (2006.01)

Patent

CA 2556018

Populations of stern cells and methods for their isolation and use are provided. These stem cell populations comprise aldehyde dehydrogenase positive (ALDHbr) cells isolated from bone marrow, and ALDHbr CD105+ cells derived from any stem cell source. These populations may also comprise cells expressing such surface markers as CD34, CD38, CD41, CD45, CD105, CD133, CD135, CD117, and HLA-DR, and/or are substantially free from such cell surface markers as CD3, CD7, CD 10, CD 13, CD 14, C1319, CD33, CD35, CD56, CD 127, CD 138, and glycophorin A. The population may also comprise cells expressing CD90. The stem cell populations of the invention are isolated from a stem cell source such as bone marrow, peripheral blood, umbilical cord blood, and fetal liver. Methods of the invention comprise isolating and purifying stem cell populations from stem cell sources, and methods of using these cells to reconstitute, repair, and regenerate tissues.

Il est fourni des populations de cellules souches et des procédés pour leur isolation et leur utilisation. Ces populations de cellules souches comprennent des cellules d'aldéhyde de déshydrogénase positive (ALDH?br¿) isolées de la moelle osseuse et des cellules ALDH?br¿ CD105?+¿ dérivées d'une quelconque source de cellules souches. Ces populations peuvent également comprendre de cellules exprimant des marqueurs de surfaces tels que CD34, CD38, CD41, CD45, CD105, CD133, CD135, CD117 et HLA-DR et/ou sont pratiquement libres de marqueurs de surfaces de cellules tels que CD3, CD7, CD 10, CD 13, CD 14, C1319, CD33, CD35, CD56, CD 127, CD 138, et de glycophorine A. La population peut également comprendre des cellules exprimant CD90. Les populations de cellules souches de l'invention sont isolées d'une source de cellules souches telle que la moelle épinière, le sang périphérique, le sang du cordon ombilical et le foie foetal. Des procédés de l'invention comprennent l'isolation et la purification de populations de cellules souches à partir des sources des cellules souches, et des procédés consistant à utiliser ces cellules pour reconstituer, réparer et régénérer des tissus.

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