Improved methods for diagnostic imaging involving the use of...

Details Improved methods for diagnostic imaging involving the use of... Improved methods for diagnostic imaging involving the use of...

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 8/14 (2006.01) A61K 9/127 (2006.01) A61K 9/133 (2006.01) A61K 47/24 (2006.01) A61K 47/34 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2263924

Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

Procédés améliorés pour obtenir une image d'une région interne d'un patient, en particulier du système cardio-vasculaire. Les réalisations de l'invention comprennent l'administration au patient d'un agent de contraste contenant une composition à vésicules. Cette composition contient des vésicules lipidiques ou polymères et un gaz ou un précurseur gazeux, combinées à un vasodilatateur pour les coronaires. Le patient subit un balayage au moyen d'un procédé d'imagerie diagnostique, tel que le procédé à ultrasons, de manière qu'une image visible de la région d'observation soit obtenue. Ces procédés sont particulièrement utiles pour diagnostiquer la présence de tissus malades ainsi que pour mesurer le débit sanguin dans le système cardio-vasculaire d'un patient.

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