Therapeutic agent for glaucoma comprising rho kinase...

Details Therapeutic agent for glaucoma comprising rho kinase... Therapeutic agent for glaucoma comprising rho kinase...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/138 (2006.01) A61K 31/343 (2006.01) A61K 31/353 (2006.01) A61K 31/437 (2006.01) A61K 31/4409 (2006.01) A61K 31/4412 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/551 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2506464

It is intended to establishing the usefulness as a remedy for glaucoma of a combination of an Rho kinase inhibitor, which has a novel function mechanism, with a .beta.-blocker. By combining the Rho kinase inhibitor with the .beta.- blocker, the effects of lowering ocular tension of these compounds can be complemented and/or potentiated each other. Concerning the administration form, they can be administered either combinedly or as a mixed preparation.

L'objectif de l'invention est de démontrer l'utilité thérapeutique d'une association comprenant un inhibiteur de la Rho-kinase, possédant un nouveau mécanisme de fonctionnement, et un bêtabloquant pour traiter le glaucome. Grâce à l'association de l'inhibiteur de la Rho-kinase et du bêtabloquant, les effets de réduction de la tension oculaire produits par ces composés peuvent se compléter et/ou se potentialiser. Ces composés peuvent être administrés de façon combinée ou sous la forme d'une préparation mixte.

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