C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 35/12 (2006.01) A61K 47/42 (2006.01) C12N 15/113 (2010.01) A61K 31/713 (2006.01)
Patent
CA 2587962
The present invention is directed to methods of transfecting cells with siRNA, by contacting a transfection complex with one or more cells, where the transfection complex includes a transport polymer and siRNA. The transport polymer may include for example, H3K8b and/or structurally similar compounds. The invention is also directed to such transfection complexes, and to compositions that include such transfection complexes. The invention is further directed to methods of treating patients using the transfection complexes of the present invention.
L'invention concerne des méthodes de transfection de cellules au moyen de petits ARN interférents (siARN), consistant à mettre en contact un complexe de transfection avec au moins une cellule, ce complexe de transfection contenant un polymère de transport et un siARN. Le polymère de transport peut contenir par exemple H3K8b et/ou des composés structurellement similaires. L'invention concerne également ces complexes de transfection, ainsi que des compositions les contenant. L'invention concerne encore des méthodes de traitement de patients au moyen desdits complexes de transfection.
Sim & Mcburney
University Of Maryland Baltimore
LandOfFree
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