3-de-0-methylfortimicins

C - Chemistry – Metallurgy – 07 – H

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260/358.5

C07H 15/22 (2006.01)

Patent

CA 1132588

Abstract of the Disclosure Described are 3-de-0-methyfortimicins A and B and 4-N-acyl and 4-N-alkyl-3-de-0-methylfortimicin B derivatives, and their preparation, which compounds are useful as anti- biotics or as intermediates for preparing other useful deriva- tives having antibacterial activity. The compounds have the following structural formula Image whcrein R is hydrogen, acyl, aminoacyl, N-monoloweralkylamino- acyl, N.N-diloweralkylaminoacyl, hydroxy-substituted amino- acyl, alkyl, aminoalkyl, N-monoloweralkylaminoalkyl, N.N- diloweralkylaminoalkyl or hydroxy-substituted aminoalkyl and the pharmaceutically acceptable salts thereof, for example, salts formed from hydrochloric, sulfuric, and phosphoric acids.

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